Unmet Need in Breast Cancer

Challenges and Statistics for Breast-conserving surgery

The objective of breast-conserving surgery is to ensure no cancer is left behind. However, until now, the only way to estimate what residual cancer might remain inside the cavity is by looking outside the cavity at the margins of removed tissue. Positive margins infer that cancer has been left behind.

 

In approximately 20-40% of cancer surgeries, repeat surgeries are required due to positive margins.1 2 3

 

For the surgeon, balancing the need to ensure cancerous tissue has been removed while preserving tissue is a perpetual challenge in breast-conserving surgery.

 

 

RESIDUAL CANCER

 

19%

of patients who have negative margins after lumpectomy have residual cancer 4

 

RE-EXCISION

 

20-40%

of breast cancer patients require a second surgery 1 2 3

 

PATHOLOGY

 

< 0.1%

of the lumpectomy specimen surface is examined post-surgery by pathology due to practical limitations8

 

RESULTS OF SECOND SURGERIES

 

65%

of patients who have positive margins after lumpectomy do not have residual cancer found in subsequent resections 4

 

MORTALITY

 

25%

of women who have local breast cancer recurrence do not survive 7

 

 

 

Ongoing research and development at Lumicell aims to change this. See how

 

*CAUTION: LUMISIGHT and Lumicell Direct Visualization System (DVS) are investigational products that are limited by Federal (or United States) law to investigational use. LUMISIGHT and Lumicell DVS are not authorized for marketing for any indication in any jurisdiction.

 

References:
1 McCahill LE, Single RM, Aiello Bowles EJ, et al. Variability in reexcision following breast conservation surgery. JAMA 2012; 307: 467-75.
2 Havel L, Naik H, Ramirez L, et al. Impact of the SSO-ASTRO margin guideline on rates of re-excision after lumpectomy for breast cancer: a meta-analysis. Ann Surg Oncol 2019;26:1238-44. 10.1245/s10434-019-07247-5
3 Chagpar AB, Killelea BK, Tsangaris TN, Butler M, et al. A Randomized, Controlled Trial of Cavity Shave Margins in Breast Cancer. N Engl J Med. 2015 Aug 6;373(6):503-10.
4 Tang R, Coopey SB, Specht MC, et al. Lumpectomy specimen margins are not reliable in predicting residual disease in breast conserving surgery. Am J Surg 2015;210(1):93–8
5 Moran MS, Schnitt SJ, Giuliano AE, et al. Society of Surgical Oncology–American Society for Radiation Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Stages I and II Invasive Breast Cancer. J Clin Oncol 2014;32(14):1507–15.
6 Morrow M, Van Zee KJ, Solin LJ, et al. Society of Surgical Oncology–American Society for Radiation Oncology–American Society of Clinical Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Ductal Carcinoma in Situ. Pract Radiat Oncol 2016;6(5):287–95
7 Clarke M, Collins R, Darby S, et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005;366:2087–106

8 Based on comparison of the surface area of a lumpectomy specimen, the number of pathology slides examined and the dimensions of the section.